Product name:

Nicergoline

Empirical formula:

C₂₄H₂₆BrN₃O₃

Molecular weight:

484.4

CAS:

[27848-84-6]

Description:

White to slightly yellowish powder of characteristic odor.

Identity

    Specific optical rotation:

4.8 to 5.8°

    IR:

Complies

Appearance of solution

    Clarity:

Complies

    Color:

Complies

Melting point:

133 – 137°C

Loss on drying:

NMT 2.0%

Related substances

    Nor-nicergoline (B):

NMT 0.5 %

    Chloronicergoline (A):

NMT 0.4 %

    Alpha, alpha-Nicergoline (F):

NMT 0.3 %

    MeLUOL (C):

NMT 0.2 %

    Bromonicotinic acid (D):

NMT 0.1 %

    10-alpha-Hydroxy-nicergoline (E):

NMT 0.2 %

    Dihydro-nicergoline (G):

NMT 0.1 %

    Unidentified impurity individually:

NMT 0.1 %

    Sum of impurities:

NMT 1.0 %

Water content:

NMT 0.5 %

Sulphated ash:

NMT 0.1 %

Residual solvents

    Acetone:

NMT 3,000 ppm

    Diethyl ether:

NMT 5,000 ppm

    Ethanol:

NMT 1,000 ppm

    Methanol:

NMT 1,000 ppm

    Toluene:

NMT 500 ppm

    Dichloromethane:

NMT 500 ppm

Assay

    Related to anhydrous and solvent-free subtance

99.0 – 101.0 %